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. 2023 Jan 4;111(1):92–105.e5. doi: 10.1016/j.neuron.2022.10.008

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Presynaptic input to and postsynaptic targets of dorsal horn Kcnip2^GlyT2 neurons

(A) Spontaneous EPSCs in a Kcnip2^GlyT2-tdTom neuron in the absence and presence of 20 μM icilin.

(B) Cumulative frequency distribution of EPSC interevent intervals.

(C) Anterograde tracing from Kcnip2^GlyT2 neurons. Green (WGA)-only neurons are postsynaptic targets of Kcnip2^GlyT2-tdTom neurons (red). Scale bar, 100 μm.

(D) Excitatory (Lmx1b) or inhibitory (Pax2) neurons postsynaptic to Kcnip2^GlyT2-tdTom neurons.

(E) Retrograde labeling of lamina I spinoparabrachial neurons with tdTom and optogenetic stimulation of Kcnip2^GlyT2 neurons.

(F) (Left) Representative IPSC traces of a lamina I spinoparabrachial neuron evoked by optogenetic stimulation of Kcnip2^GlyT2 neurons. IPSCs were completely blocked by bicuculline (20 μM) and strychnine (0.5 μM). (Right) Group data, n = 6. Mean ± SEM.