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. 2022 Dec 20;14(24):10009–10026. doi: 10.18632/aging.204439

Figure 4.

Figure 4

circ_0066715 regulates the miR-486-5p/ETS1 axis. (A) ETS1 binding site to miR-486-5p. (B) Luciferase reporter. **P < 0.01. (n=3, ANOVA with Bonferroni’s post test). (C) ETS1 mRNA expression in miR-486-5p overexpressing RA-FLS cells. **P < 0.01. (n=3, ANOVA with Bonferroni’s post test). (D, E) Expression of ETS1 protein in miR-486-5p overexpressed RA-FLS cells was performed by western blotting. **P < 0.01. (n=3, ANOVA with Bonferroni’s post test). (F) ETS1 expression in FLS cells (IF,×200). (G) IL-4 expression in FLS cells (IF,×200). (H) TNF-α expression in FLS cells (IF,×200).