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Effects of pneumolysin (Pln; 8.37 and 41.75 ng/ml) on the production of LTB4 and PGE2 by unstimulated and FMLP (1 μM)-activated neutrophils. The results of 9 (PGE2) or 10 (LTB4) experiments using cells from different donors are expressed as the mean ± the SEM. Asterisks indicate P < 0.05 for comparison with the appropriate pneumolysin-free control systems.
