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Ubiquitination and degradation of AR by the ubiquitin-proteasome system (UPS). Abbreviations: AR, androgen receptor; E1, ubiquitin ligase E1; E2, ubiquitin ligase E2; E3, ubiquitin ligase E3; Ub, ubiquitin; UBA, ubiquitin-associated domains; UBL, ubiquitin-like domains.
