Figure 2.

Immunohistochemistry examination for critical acid-base transporters. Panels a and b show expression of the electrogenic sodium bicarbonate cotransporter, isoform 1. Panel a shows intact basolateral sodium bicarbonate cotransporter, isoform 1 immunolabel in proximal tubule segments in this patient. Panel b shows sodium bicarbonate cotransporter, isoform 1 immunolabel expression in control tissue. Sodium bicarbonate cotransporter, isoform 1 immunolabel does not differ detectably between case and control tissues. Panels c and d show immunohistochemistry for H⁺-ATPase in the case and control tissues, respectively. In both, intact H⁺-ATPase expression with apical polarization in type A intercalated cells is not detectably different between case and control tissues. Panels e and f show Rhesus C glycoprotein immunolabel expression in the case and control tissue. Panels e and f show Rhesus C glycoprotein immunolabel expression in the case and control tissues, respectively. Apical and basolateral Rhesus C glycoprotein immunolabel in intercalated cells is present in both and does not differ detectably between case and control tissues.