Table 1.

Summary of previous reports of metabolic acidosis with ICI therapy

Case # [Ref]	Cancer	Drug	Target	Urine pH	Serum creatinine (mg/dl)	Peak creatinine (mg/dl)	Urine anion gap	AIN on kidney biopsy
1S11	Lung	Pembrolizumab	PD-1	6.5	1.5	1.5	10	Yes
2 S11	Melanoma	Nivolumab	PD-1	6.3	1.5	4.9	48	Yes
3S11	Renal Cell	Nivolumab	PD-1	6.7	2.1	2.6	NA	NA
4S10	Lung	Nivolumab followed by pembrolizumab	PD-1	6.5	0.55	1.67	36	NA
5S10	Melanoma	Pembrolizumab	PD-1	6.0	1.4	2.0	49	Yes
6S13	Lung	Pembrolizumab	PD-1	6.0	0.8	0.8	36	Yes
7S12	Squamous cell carcinoma of the skull	Cemiplimab	PD-1	6.0	1.3	2.8	39	Yes
Case	Lung	Pembrolizumab	PD-1	6.0	0.6	0.6	26	No

AIN, acute interstitial nephritis; ICI, immune checkpoint inhibitor; NA, not available; PD-1, programmed death-1.