Table 2.

Teaching points

Teaching points
ICI-RTA is a unique immune-related adverse event.
ICI-RTA is not easily classifiable with our current criteria for RTA.
The novel form of RTA, which we term type V RTA, is characterized by impaired urinary ammonia excretion, hypokalemia, intact ability to acidify the urine, and evidence of intact proximal tubule citrate transport.
The presence of this unique RTA may be a common finding in ICI-associated RTA and may be independent of associated AKI.

AKI, acute kidney injury; ICI, immune checkpoint inhibitor; RTA, renal tubular acidosis.