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. 2023 Jan 10;14:35. doi: 10.1038/s41467-022-35343-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Select examples of experimental fractional drug release profiles (orange circles) in comparison to predicted fractional drug release profiles (blue circles) generated by the LGBM model. These include dexamethasone-loaded PLGA MPs (DEX-PLGA); temozolomide-loaded PLGA MPs (TMZ-PLGA); fluorouracil-loaded PLGA MPs (5-FU-PLGA); and paclitaxel-loaded PVL-co-PAVL cross-linked cylinders. b Shapley additive explanations (SHAP) analysis for the 15-feature LGBM model. The impact of each feature on fractional drug release is illustrated through a swarm plot of their corresponding SHAP values. The color of the dot represents the relative value of the feature in the dataset (high-to-low depicted as pink-to-blue). The horizontal location of the dots shows whether the effect of that feature value contributed positively or negatively in that prediction instance (x-axis). Source data are provided as a Source Data file.