Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 10;14:35. doi: 10.1038/s41467-022-35343-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — The design of both the SA-PLGA and OLA-PLGA was based on SHAP analysis of the trained LGBM model. Three independent batches of both formulations were prepared, and their experimental drug release was characterized in 0.5 wt% sodium dodecyl sulfate (SDS) to ensure sink conditions throughout the experiments. The fractional experimental drug release profiles for SA-PLGA and OLA-PLGA are plotted together as pink circles with a solid line (SA-PLGA) and blue hexagons with a solid line (OLA-PLGA), respectively. In both cases, the standard deviation (STD) observed for these experimental drug release measurements is displayed as a colored halo (n = 3). The fractional drug release profiles predicted by the LGBM model are also shown as pale pink circles with a broken line (SA-PLGA) and pale blue hexagons with a broken line (OLA-PLGA), respectively. Source data are provided as a Source Data file.