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Table highlighting key design criteria for “fast” and “slow” release PLGA MPs based on SHAP analysis of the 15-feature LGBM model and the observed trends in the PCA plots
| Feature/property | Value for “fast” release | Value for “slow” release |
|---|---|---|
| Drug MW | Low | Medium/high |
| Polymer MW | Low | Medium/high |
| Drug TPSA | Low | Low/medium |
| SA-V | Low | Low/medium |
| Initial D/M ratio | Low | Low |
| DLC | Low | Low/medium |
