Table 2.
Comparison between the conventional Cox proportional hazards models and the structural marginal models, the latter adjusted only for time-varying estimated glomerular filtration rate, for the assessment of the association of time-varying hyperparathyroidism, hypocalcemia, and hyperphosphatemia with allograft dysfunction
| Cox proportional hazards model (unadjusted) | HR | 95% CI | P value |
|---|---|---|---|
| Hyperparathyroidism | 3.13 | 1.99–4.92 | <0.001 |
| Hypocalcemia | 1.62 | 1.16–2.27 | 0.005 |
| Hyperphosphatemia | 1.99 | 1.36–2.91 | <0.001 |
| Marginal structural model (unadjusted) | |||
| Hyperparathyroidism | 2.79 | 1.80–4.34 | <0.001 |
| Hypocalcemia | 1.89 | 1.37–2.60 | <0.001 |
| Hyperphosphatemia | 1.32 | 0.87–2.00 | 0.193 |
CI, confidence interval; HR, hazard ratio.