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. 2023 Jan 10;14:131. doi: 10.1038/s41467-022-35747-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic illustration of a compartmental model consisting of a soma (spiking unit) and two dendrites (passive integrators). The apical dendrite can integrate excitatory synapses comprising AMPA and NMDA currents. b Membrane voltage responses to current injections of the same amplitude are applied individually to each compartment. Notice the electrical segregation caused by the resistance between the three neuronal compartments. c Somatic responses to a varying number of simultaneous synaptic inputs (5–35 synapses). Left: control EPSPs, right: EPSPs in the presence of NMDA blockers. d) Input-output function of the apical dendrite as recorded at the soma. The dotted line represents a linear function. Notice the shift from supralinear to the sublinear mode when NMDARs are blocked. The simulations and analysis code related to the above figure can be executed in any browser by following this link: https://github.com/Poirazi-Lab/dendrify/blob/main/paper_figures/Fig2_notebook.ipynb.