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. 2023 Jan 10;13:519. doi: 10.1038/s41598-023-27737-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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AT1a receptor loss modulated M1/M2 macrophage polarization in the denervated gastrocnemius muscle. (a) Immunostaining of gastrocnemius muscle in each AT1a^+/+ and AT1a^−/− mice at 21 days postdenervation. Immunostaining shows codistribution of M1 and M2 macrophages. Anti-F4/80 antibody binds M1 macrophages and M2 macrophages (brown color). Anti-CD206 antibody binds M2 macrophages (green fluorophore). CD206^-/F4/80⁺ cells are M1 macrophages. CD206⁺/F4/80⁺ cells are M2 macrophages. Scale bar: 50 μm. (b, c) The degrees of infiltrated M1 macrophage (b) and M2 macrophage (c) were shown as the fold increase or decrease in the Den group compared with the Cont group in immunohistochemistry analysis. AT1a^+/+-Cont group, n = 6; AT1a^+/+-Den group, n = 7; AT1a^−/−-Cont group, n = 5; AT1a^−/−-Den group, n = 6. Values are means ± SE. ^*P < 0.05.