Table 1.

Animal characteristics at 7 and 21 days postdenervation.

	AT1a+/+-Cont (n = 6)	AT1a+/+-Den, 7 days (n = 7)	AT1a+/+-Den, 21 days (n = 7)	AT1a−/−-Cont (n = 5)	AT1a−/−-Den, 7 days (n = 6)	AT1a−/−-Den, 21 days (n = 6)
Body weight (g) pre-operation	24.6 ± 0.31	24.5 ± 0.42	24.3 ± 0.39	28.0 ± 0.88##	26.7 ± 0.63	25.5 ± 0.97
Body weight (g) pre-tissue harvest	27.8 ± 0.47	25.0 ± 0.42**	26.0 ± 0.46	30.1 ± 1.03#	27.2 ± 0.65**, §	26.5 ± 0.89**
Grip strength (N)	2.49 ± 0.08	2.63 ± 0.07	2.45 ± 0.08	2.75 ± 0.07#	2.79 ± 0.03	2.57 ± 0.09
Grip strength (N)/body weight (kg)	104.39 ± 2.58	110.43 ± 3.24	103.94 ± 3.37	99.48 ± 2.19	103.49 ± 1.87	99.16 ± 3.22
Skeletal muscles (mg)
Gastrocnemius	144.68 ± 2.25	89.67 ± 1.10**	50.82 ± 0.71**	135.14 ± 2.53#	93.95 ± 3.86**	53.18 ± 2.77**
Tibialis anterior	52.77 ± 0.57	39.23 ± 0.64**	25.49 ± 0.10**	55.90 ± 1.39	42.12 ± 1.43**	25.16 ± 1.53**
Soleus	8.53 ± 0.43	6.78 ± 0.17**	5.21 ± 0.13**	8.38 ± 0.41	6.78 ± 0.17**	5.63 ± 0.40**
Skeletal muscles (mg)/body weight (g)
Gastrocnemius	5.22 ± 0.12	3.60 ± 0.10**	1.96 ± 0.03**	4.50 ± 0.07##	3.45 ± 0.08**	2.00 ± 0.05**
Tibialis anterior	1.90 ± 0.03	1.57 ± 0.03**	0.98 ± 0.04**	1.87 ± 0.06	1.55 ± 0.03**	0.95 ± 0.03**
Soleus	0.31 ± 0.02	0.25 ± 0.01**	0.20 ± 0.01**	0.28 ± 0.01	0.25 ± 0.001	0.21 ± 0.01**

Values are means ± SE. **P < 0.01 vs the same group control; ^#P < 0.05 and ^##P < 0.01 vs AT1a^+/+-Cont; ^§P < 0.05 vs AT1a^+/+-Den (7 days).