Table 3.

P2X receptor structures solved to date. Structures are characterised by their conformation, bound ligands, resolution, method of determination and length of the construct

Structure	Reference	Ligands’ bound and resolution	Receptor conformation	Method	Receptor construct
Zebrafish P2X4 receptor (zfP2X4)	[10, 92, 119]	Apo 2.9–3.5 Å ATP 2.8 Å CTP 2.8 Å	Closed, open	X-ray crystallography	Truncated
Rat P2X4 receptor (rP2X4)	[120]	N/A	N/A	NMR spectroscopy	Head domain
Gulf Coast tick P2X receptor (amP2X)	[121]	ATP + Zn2+ 2.9 Å	Pre-open	X-ray crystallography	Truncated
Human P2X3 receptor (hP2X3)	[89, 101, 94]	Apo 3.0 Å ATP 2.8–2.9 Å 2MeSATP 3.1 Å TNP-ATP 3.3 Å A317491 3.1 Å Gefapixant 3.4 Å ATP + Mg2+ 3.8 Å ATP + Ca2+ 3.3 Å	Open, closed, desensitised	X-ray crystallography	Truncated
Panda P2X7 receptor (pdP2X7)	[102]	Apo 3.4 Å ATP + A804598 3.9 Å A740003 3.6 Å GW791343 3.3 Å JNJ47965567 3.2 Å AZ10606120 3.5 Å A804598 3.4 Å	Closed	X-ray crystallography	Truncated
Chicken P2X7 receptor (ckP2X7)	[122]	TNP-ATP 3.1 Å	Closed	X-ray crystallography	Truncated
Rat P2X7 receptor (rP2X7)	[88]	Apo 2.9 Å ATP 3.3 Å	Closed, open	Cryo-EM	Full length