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The evolution of epigenetic and epigenomic therapies. The first epigenetic therapeutics were first discovered in the 1960s but the first approval did not come until the early 2000s. Development in the field has accelerated markedly over the past 20 years, with epigenomic programming being the most recent advance. Green = DNMT inhibitor milestones; orange = HDAC inhibitor milestones; purple = 3rd generation epigenetic therapeutic milestones; blue = epigenomic programming milestones
