Figure 6.

All figures are presented as mean (solid middle line) ± SEM (shaded area). To further investigate our finding that 100 mg/kg of ketamine decreased total EtOH intake and distance travelled, we calculated intake and movement patterns across the DID session on day 17 by sex: females (top), males (bottom). Intake patterns further demonstrate that female mice in the 100 mg/kg group (A) consume a disproportionately high amount in the early part of the 2-hr DID session, potentially resulting in sedation toward the middle of the session (B). Males shown for comparison (C, D). These results indicate that female mice were not sedated from the 100 mg/kg ketamine injection 12-hours prior, but rather the decrease in total distance travelled is driven by the mouse’s frontloading behavior.