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Schematic of the cotinine metabolism pathway. (1) Nicotine, (2) COT, (3) 3HC, (4) COX, (5) COT-glucuronide, and (6) norcotinine. Percentages [taken from (Rangiah et al., 2011)] indicate the levels of each metabolite as a percentage of total cotinine metabolites in the urine from smokers.
