Table 10.

Results of the mixed models per-protocol analyses on secondary outcomes—indicators of physical and mental health

	Intervention group N = 54	Control group N = 27	Model A N = 81			Model B N = 76
	Mean (sd)	Mean (sd)	B (95% CI)	P value	d	B (95% CI)	P value	d
ADL limitations
Baseline	0.11 (0.37)	0.37 (0.74)
9 months	0.15 (0.41)	0.44 (0.75)	− 0.12 (− 0.23 to − 0.003)	.045	.22	− 0.13 (− 0.26 to − 0.01)	.03	.24
Experienced frailty
Baseline	0.11 (0.05)	0.12 (0.08)
9 months	0.11 (0.06)	0.11 (0.08)	0.01 (− 0.01 to 0.02)	.37	.16	0.01 (− 0.01 to 0.02)	.27	.16
Mental health
Baseline	81.77 (11.14)	79.47 (15.06)
9 months	81.28 (13.73)	84.00 (12.40)	− 2.89 (− 5.41 to − 0.37)	.03	.23	− 2.73 (− 5.46 to − 0.002)	.05	.22
	Intervention group N = 35	Control group N = 20	Model A N = 55			Model B N = 50
	Mean (sd)	Mean (sd)	B (95% CI)	P value	d	B (95% CI)	P value	d
Depressive symptoms
Baseline	8.66 (6.07)	8.30 (6.90)
9 months	7.23 (5.62)	8.30 (7.66)	− 0.74 (− 2.15 to 0.68)	.31	.12	− 0.89 (− 2.42 to 0.63)	.25	.14

Model A: adjusted for y at baseline, age, and sex. Model B: adjusted for y at baseline, age, sex, education, and APOE ε4 carrier status. PA Physical activity as measured in daily number of steps taken, ADL Activities of daily living, IGF-1 Insulin-like growth factor 1, HDL High-density lipoprotein, d Cohen’s d