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. 2023 Jan 11;15:12. doi: 10.1186/s13195-022-01123-3

Table 7.

Results of the mixed models analyses investigating the effect of a >= 35% increase in physical activity on secondary outcome measures of physical and mental health

 > = 35% increase PA T2
N = 35
 < 35% increase PA T2
N = 45
Model A
N = 80
Model B
N = 75
Mean (sd) Mean (sd) B (95% CI) P value d B (95% CI) P value d
ADL limitations
 Baseline 0.17 (0.45) 0.22 (0.60)
 9 months 0.14 (0.36) 0.33 (0.67)  − 0.08 (− 0.19 to 0.02) .12 .15  − 0.13 (− 0.24 to − 0.02) .02 .24
Experienced frailty
 Baseline 0.10 (0.05) 0.12 (0.07)
 9 months 0.10 (0.05) 0.12 (0.07)  − 0.01 (− 0.02 to 0.003) .15 .16  − 0.01 (− 0.02 to 0.003) .18 .16
Mental health
 Baseline 82.81 (10.73) 79.53 (13.84)
 9 months 83.99 (10.12) 82.81 (10.73) 0.79 (− 1.59 to 3.17) .52 .06 0.79 (− 1.78 to 3.37) .55 .06

 >  = 35% increase PA T2

N = 26

 < 35% increase PA T2

N = 29

Model A

N = 55

Model B

N = 50

Mean (sd) Mean (sd) B (95% CI) P value d B (95% CI) P value d
Depressive symptoms
 Baseline 7.04 (5.29) 9.86 (6.95)
 9 months 6.08 (4.83) 9.00 (7.33)  − 0.36 (− 1.76 to 1.04) .61 .06  − 0.86 (− 2.40 to 0.68) .28 .14

Model A: adjusted for y at baseline, age, and sex. Model B: adjusted for y at baseline, age, sex, education, and ApoE-ε4 carrier status. PA Physical activity as measured in daily number of steps taken, ADL Activities of daily living, IGF-I Insulin-like growth factor 1, HDL High-density lipoprotein, d Cohen’s d