TABLE 3.
Differentially expressed microRNAs (miRNAs) in fracture healing (A) and non‐union (B)
| Validated miRNA | Independent reports (n) | Author (year), ↑/↓ |
|---|---|---|
| (A) Fracture healing | ||
| Upregulated | ||
| miR‐125b(‐3p/5p) | 4 | Furuta, T. (2016) 91 ↑, Bourgery, M. (2021) 78 ↑, Seeliger, C. (2014) 45 ↑, Ito, S. (2021) 100 ↑ |
| miR‐148(a‐3p) | 3 | Liu, H. (2018) 84 ↑, Seeliger, C. (2014) 45 ↑, Bourgery, M. (2021) 78 ↑ |
| miR‐25(‐3p) | 3 | Jiang, Y. (2020) 96 ↑, Lang, Y. (2019) 95 ↑, Seeliger, C. (2014) 45 ↑ |
| miR‐100(‐5p) | 3 | Seeliger, C. (2014) 45 ↑, Dai, Z.Q. (2022) 164 ↑, Yang, W. (2021) 75 ↑ |
| miR‐187(‐3p) | 2 | Zhang, J. (2021) 65 ↑, Yuan, H.F. (2015) 72 ↑ |
| miR‐206 | 2 | He, B. (2016) 82 ↑, Huang, Y. (2021) 112 ↑ |
| miR‐19b | 2 | Zarecki, P. (2020) 71 ↑, Huang, Y. (2021) 99 ↑ |
| miR‐23(a‐3p) | 2 | Seeliger, C. (2014) 45 ↑, Zarecki, P. (2020) 71 ↑ |
| miR‐24(‐3p) | 2 | He, B. (2016) 82 ↑, Seeliger, C. (2014) 45 ↑ |
| miR‐26a(‐5p) | 2 | Li, Y. (2015) 102 ↑, Xiong, Y. (2019) 73 ↑ |
| miR‐34a(‐5p) | 2 | Yuan, H.F. (2015) 72 ↑, Liu, H. (2019) 118 ↑ |
| miR‐122(a‐5p) | 2 | Seeliger, C. (2014) 45 ↑, Silva, A.M. (2018) 86 ↑ |
| miR‐136(‐3p/5p) | 2 | Bourgery, M. (2021) 78 ↑, Yu, H. (2021) 122 ↑ |
| Downregulated | ||
| miR‐124(a‐3p) | 3 | Cui, Y. (2019) 108 ↓, Zou, L. (2017) 57 ↓, Seeliger, C. (2014) 45 ↓ |
| miR‐144(‐3p/5p) | 3 | Bourgery, M. (2021) 78 ↓, He, B. (2016) 82 ↓, Zhang, D. (2021) 79 ↓ |
| miR‐494(‐3p) | 2 | He, B. (2016) 82 ↓, Hadjiargyrou, M. (2016) 103 ↓ |
| miR‐497(‐3p) | 2 | Ji, X. (2021) 62 ↓, He, B. (2016) 82 ↓ |
| Up and downregulated | ||
| miR‐21(‐5p) | 9 | Liu, Y. (2019) 109 ↑, Sheng, J. (2019) 115 ↓, Sun, Y. (2015) 101 ↑, Hadjiargyrou M. (2015) 103 ↑, Sun, X. (2020) 46 ↑, Seeliger, C. (2014) 45 ↑, Zarecki, P. (2020) 71 ↑, Strauss, F.J. (2020) 128 ↓, Silva, A.M. (2018) 86 ↑ |
| miR‐214(‐3p/5p) | 8 | Xin, Z. (2020) 55 ↓, Zhou, L.‐G. (2019) 111 ↓, Teng, J.‐W. (2018) 113 ↓, Li, Q.S. (2017) 63 ↑, Li, K.‐C. (2016) 104 ↓, Chen, J. (2021) 130 ↓, Wang, X. (2021) 81 ↓, Li, K.C. (2017) 106 ↓ |
| miR‐140(‐3p/5p) | 7 | Waki, T. (2016) 129 ↓, Jiao, J. (2020) 120 ↑, Liu, Q.‐P. (2019) 48 ↑, Bourgery, M. (2021) 78 ↓, Hadjiargyrou, M. (2016) 103 ↑, Li, K.‐C. (2016) 104 ↓, Takahara, S. (2018) 85 ↓ |
| miR‐223(‐3p/5p) | 5 | Bourgery, M. (2021) 78 ↓, He, B. (2016) 82 ↓, Seeliger, C. (2014) 45 ↑, Wang, B. (2021) 68 ↑, Dietz, C. (2019) 70 ↑ |
| miR‐142(a‐3p/5p) | 4 | Bourgery, M. (2021) 78 ↓, He, B. (2016) 82 ↓, Hadjiargyrou, M. (2016) 103 ↓, Tu, M. (2017) 93 ↑ |
| miR‐181a(‐3p/5p) | 4 | Waki, T. (2016) 129 ↓, Takahara, S. (2018) 85 ↑, Yuan, H.F. (2015) 72 ↑, Bourgery, M. (2021) 78 ↑ |
| miR‐335(‐5p) | 3 | Janko, M. (2019) 166 ↓, Hu, H. (2021) 90 ↑, Zarecki, P. (2020) 71 ↑ |
| miR‐92a(‐3p) | 3 | Murata, K. (2014) 64 ↑, Janko, M. (2019) 166 ↑, Hu, L. (2021) 67 ↓ |
| miR‐22(‐3p) | 3 | He, B. (2016) 82 ↓, Zhang, X. (2020) 47 ↑, Weilner, S. (2015) 66 ↑ |
| miR‐532‐3p | 2 | Zarecki, P. (2020) 71 ↑, Silva, A.M. (2018) 86 ↓ |
| miR‐222(‐3p) | 2 | Jiang, C. (2020) 97 ↓, Takahara, S. (2018) 85 ↑ |
| miR‐328‐3p | 2 | Xie, W. (2020) 56 ↓, Weilner, S. (2015) 66 ↑ |
| miR‐429 | 2 | Huang, J. (2016) 105 ↑, Silva, A.M. (2018) 86 ↓ |
| miR‐181c(‐3p/5p) | 2 | Bourgery, M. (2021) 78 ↓, Yuan, H.F. (2015) 72 ↑ |
| miR‐182(‐5p) | 2 | Bourgery, M. (2021) 78 ↑, Yan, Z.‐W. (2021) 69 ↓ |
| miR‐10a‐5p | 2 | Bourgery, M. (2021) 78 ↓, Weilner, S. (2015) 66 ↑ |
| (B) Non‐union | ||
| Upregulated | ||
| miR‐149 | 2 | Li, G.J. (2020) 144 ↑, Chen, H. (2017) 134 ↑ |
| miR‐221‐3p | 2 | Takahara, S. (2020) 139 ↑, Chen, H. (2017) 134 ↑ |
| miR‐31‐5p | 2 | Waki, T. (2015) 140 ↑, Orth, M. (2019) 141 ↑ |
| Downregulated | ||
| miR‐451‐5p | 2 | Waki, T. (2015) 140 ↓, Takahara, S. (2020) 139 ↓ |
| Up and downregulated | ||
| miR‐140‐5p | 3 | Guo, P.‐Y. (2019) 142 ↑, Waki, T. (2016) 129 ↓, Orth, M. (2019) 141 ↑ |