Table 1. Results of the ConSurf Server for Residues Whose Mutation by Ala Lowers the Activation Energya.
RESIDUE | SCORE (1–9) | VARIABILITY |
---|---|---|
Asp87 | 9 | Glu |
Asp214 | 8–9 | Val, Gly, Ala, Glu, Ser |
Glu365* | 8–9 | Asp, Gln |
Lys397 | 9 | Arg |
SCORE indicates the degree of conservation of the residue (the higher the SCORE, the higher the conservation of the position of the residues in the primary sequence); VARIABILITY indicates which residues can be found in the same position when considering proteins with a similar fold.