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. 2022 Dec 19;63(1):20–26. doi: 10.1021/acs.jcim.2c01337

Table 1. Results of the ConSurf Server for Residues Whose Mutation by Ala Lowers the Activation Energya.

RESIDUE SCORE (1–9) VARIABILITY
Asp87 9 Glu
Asp214 8–9 Val, Gly, Ala, Glu, Ser
Glu365* 8–9 Asp, Gln
Lys397 9 Arg
a

SCORE indicates the degree of conservation of the residue (the higher the SCORE, the higher the conservation of the position of the residues in the primary sequence); VARIABILITY indicates which residues can be found in the same position when considering proteins with a similar fold.