Table 2.
Day 1 blood-based biomarker levels stratified by diagnostic group and age
| Values are median (interquartile range) | 17–39 years | P-value | 40–64 years | P-value | 65–90 years | P-value |
|---|---|---|---|---|---|---|
| GFAP, pg/mL | ||||||
| TBI/CT+ | 1612.7 (596.4–4183.3) | 1497.2 (544.8–3301.0) | 1162.0 (360.8–3351.3) | |||
| TBI/CT− (Ref: TBI/CT+) | 122.4 (22.3–420.3) | <0.001 | 159.0 (34.7–411.2) | <0.001 | 115.2 (50.0–357.7) | <0.001 |
| All TBI | 378.0 (71.7–1414.2) | 503.4 (117.8–1801.8) | 618.8 (212.3–2291.5) | |||
| OC (Ref: All TBI) | 8.4 (3.8–16.8) | <0.001 | 14.0 (7.7–27.6) | <0.001 | 26.6 (14.6–41.9) | <0.001 |
| HC (Ref: All TBI) | 5.0 (2.0–10.0) | <0.001 | 10.0 (5.0–15.0) | <0.001 | 28.5 (25.3–38.8) | <0.001 |
| UCH-L1, pg/mL | ||||||
| TBI/CT+ | 356.0 (165.8–817.0) | 313.4 (151.5–821.8) | 233.2 (158.3–559.2) | |||
| TBI/CT− (Ref: TBI/CT+) | 146.0 (73.3–286.0) | <0.001 | 176.1 (93.0–320.3) | <0.001 | 224.0 (148.1–373.9) | 0.2072 |
| All TBI | 206.1 (93.9–476.5) | 221.2 (120.2–512.7) | 230.7 (151.8–491.3) | |||
| OC (Ref:All TBI) | 116.9 (78.6–182.6) | <0.001 | 132.7 (77.2–194.7) | <0.001 | 167.3 (96.8–285.6) | 0.0957 |
| HC (Ref:All TBI) | 47.0 (37.0–68.0) | <0.001 | 74.0 (52.3–96.0) | <0.001 | 109.0 (75.3–156.8) | <0.001 |
| S100B, ug/L | ||||||
| TBI/CT+ | 0.202 (0.105–0.395) | 0.178 (0.1–0.414) | 0.149 (0.079–0.34) | |||
| TBI/CT− (Ref:TBI/CT+) | 0.106 (0.065–0.188) | <0.001 | 0.107 (0.064–0.176) | <0.001 | 0.109 (0.078–0.165) | 0.024 |
| All TBI | 0.131 (0.075–0.258) | 0.135 (0.08–0.269) | 0.128 (0.078–0.276) | |||
| OC (Ref:All TBI) | 0.088 (0.058–0.14) | <0.001 | 0.084 (0.058–0.125) | <0.001 | 0.096 (0.076–0.145) | 0.281 |
| HC (Ref:All TBI) | 0.041 (0.032–0.056) | <0.001 | 0.051 (0.035–0.066) | <0.001 | 0.043 (0.035–0.074) | <0.001 |
| NSE, ng/mL | ||||||
| TBI/CT+ | 30.54 (19.88–49.53) | 24.04 (15.25–46.19) | 18.44 (13.45–31.91) | |||
| TBI/CT− (Ref:TBI/CT+) | 18.36 (13.74–29.34) | <0.001 | 17.64 (13.04–26.70) | <0.001 | 18.64 (14.66–27.74) | 0.801 |
| All TBI | 22.83 (15.04–39.58) | 19.88 (13.83–36.2) | 18.46 (13.83–31.48) | |||
| OC (Ref:All TBI) | 15.74 (12.16–23.47) | <0.001 | 15.6 (11.55–20.12) | <0.001 | 14.99 (12.48–18.88) | 0.063 |
| HC (Ref:All TBI) | 12.13 (10.27–14.28) | <0.001 | 12.585 (11.12–15.45) | <0.001 | 13.715 (11.34–21.74) | 0.049 |
P-values are from the Wilcoxon Rank Sum test comparing the biomarkers between diagnostic groups.
Ref = reference group.