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. 2022 Oct 31;5(1):13–26. doi: 10.1096/fba.2022-00085

FIGURE 3.

FIGURE 3

Biliary fibrosis and intrahepatic cholestasis are observed by 80 days gestation in the CFTR−/− sheep. WT (A, C, E) and CFTR −/− (B, D, F) fetal sheep liver at 80 days. (A) Normal liver in a WT fetus. Note the well‐defined bile ducts in portal tracts (arrowheads). (B) Liver of a CFTR −/− fetus. Higher magnifications (C–F) of (C and E) normal liver in a WT fetus showing the well‐defined bile duct in the portal tract (arrowhead), and (D and F) the portal tract with early biliary fibrosis (arrowhead) in a CFTR −/− fetus. (F) Multiple bile ducts with indistinct lumens expand the portal tract and intrahepatic cholestasis is seen (arrow). Hematoxylin and eosin stain (A to D). 100× (A and B); bar = 200 μm. 200× (C and D); bar = 100 μm. 400× (E and F); bar = 50 μm.