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. 2023 Jan 11;16:1. doi: 10.1186/s13044-023-00146-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Histopathological and immunohistochemical images of brain metastases Histological images of metastatic papillary thyroid carcinoma (PTC). a PTC invades brain parenchyma (1/3 upper left *) (HE stain, × 40), b Image suggestive of papillary structureon papillary structure (long arrow), a follicle lined cuboidal cells with dark nucleic regularly contains colloid (short arrow) (HE × 100). c The papillary structures are covered by tumor cells without obvious papillary nuclear features (HE stain, × 400). d Tumor cells are positive Thyroglobulin (Immunohistochemistry stain, × 400). The histological image showed the majority of papillary structures in the peripheral area of tumor includes only vague papillary structures with edematous, collagenous and fibrous stroma like papillary cores, intercalating secretory follicular structures that contain colloid,. No tumor necrosis was seen and mitosis was rare. Immunohistochemistrical stain shows that tumor cells are positive for Thyroglobulin, TTF1 maker. Ki67 positivity was very low. Nuclear features of papillary thyroid carcinoma were not clear but there was no evidence of poorly differenciated or anaplastic thyroid carcinoma. The histopathological features are consistent with a high-grade papillary thyroid carcinoma