Figure 1.

Schematic of the HTLV-I genome and ZFP target sites. A schematic depicting the 5′ LTR and 3′ LTRs flanking the ∼9 kb integrated HTLV-I genome with the 3′ LTR (light blue) driving the expression of the anti-sense HBZ gene. The representative target sites of a series of ZFP within the LTR are indicated (red arrows, ZFP2-10). Transcription factor SpI binding sites and the transcription start site (TSS) in the 3′ LTR are shown in purple. The HBZ coding sequence is highlighted in dark blue.