| 1. Question/objective sufficiently described? |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
| 2. Study design evident and appropriate? |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
| 3. Method of subject/comparison group selection or source of information/input variables described and appropriate? |
1 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
| 4. Subject (and comparison group, if applicable) characteristics sufficiently described? |
2 |
2 |
2 |
2 |
2 |
1 |
2 |
2 |
2 |
2 |
2 |
1 |
| 5. If interventional and random allocation was possible, was it described? |
N/A |
N/A |
N/A |
N/A |
2 |
N/A |
N/A |
N/A |
N/A |
N/A |
N/A |
N/A |
| 6. If interventional and blinding of investigators was possible, was it reported? |
N/A |
N/A |
N/A |
N/A |
1 |
N/A |
N/A |
N/A |
N/A |
N/A |
N/A |
N/A |
| 7. If interventional and blinding of subjects was possible, was it reported? |
N/A |
N/A |
N/A |
N/A |
1 |
N/A |
N/A |
N/A |
N/A |
N/A |
N/A |
N/A |
| 8. Outcome and (if applicable) exposure measure(s) well defined and robust to measurement/misclassification bias? Means of assessment reported? |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
| 9. Sample size appropriate? |
2 |
1 |
1 |
2 |
1 |
1 |
1 |
2 |
2 |
1 |
1 |
0 |
| 10. Analytic methods described/justified and appropriate? |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
| 11. Some estimate of variance is reported for the main results? |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
| 12. Controlled for confounding? |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
| 13. Results reported in sufficient detail? |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
| 14. Conclusions supported by the results? |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
| Total score |
21 |
21 |
21 |
22 |
25 |
20 |
21 |
22 |
22 |
21 |
21 |
19 |
| Percentage |
95% |
95% |
95% |
100% |
89% |
91% |
95% |
100% |
100% |
95% |
95% |
86% |