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. 2023 Jan 11;24:8. doi: 10.1186/s12882-023-03058-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Response to eculizumab treatment. A, C Line graphs showing eGFR change in log₂ scale (y-axis) relative to month zero. X-axis indicates time in months. Upper facet shows patients receiving standard of care (SoC) treatment, lower facet shows patients receiving eculizumab treatment. Dots indicate median eGFR values for all available cases at respective months. Vertical lines indicate standard deviations. Smooth line indicates a generalized additive model fitted to the data. Grey areas indicate 95% confidence intervals for the model. B, D Line graph indicating count of cases (y-axis) with available eGFR data for each timepoint (x-axis; time in months). Patient data was grouped and colored in cases with native kidneys, or kidney allografts. Coloring is indicated in the legend to the right