Figure EV1. The effect of IMPDH inhibitors on human myeloid leukemia cells in vitro .

• A, B
  Cell viability assays were performed using WST‐1. Human CB CD34⁺ cells and human AML cell lines (with MLL‐fusions: MV4;11, MOLM13, NOMO1 and THP1, without MLL‐fusions: HL60, Kasumi‐1, OCI‐AML3 and U937), CB cells expressing MLL‐AF9 (CB‐MA9#1, 2, 3) or MLL‐ENL (CB‐MLL‐ENL#1, 2) (A) and PDX cell lines with or without MLL‐fusions (AML#1, 2, 3 or AML#4, 5, 6) (B) were treated with titrating doses of MPA (1–100 μM) for 72 h in three technical replicates. IC50 values for each experiment are summarized in Fig 1B and C. Data are shown as mean ± SEM.

Source data are available online for this figure.