Table 5. Characteristics of participants.
| Clinical characteristics | Baseline | After intervention | |
|---|---|---|---|
| Placebo | Sitagliptin | ||
| Age (years) | 58 ± 11 | ||
| Men/Women, n (%) | 9/7 (56/44) | ||
| BMI (kg/m2) | 27 ± 2 | ||
| BMI > 25.0 kg/m2, n (%) | 14 (87) | ||
| Family history of T2DM, n (%) | 11 (69) | ||
| Systolic arterial hypertension, n (%) | 9 (56) | ||
| SAP (mmHg) | 136 ± 26 | ||
| DAP (mmHg) | 77 ± 16 | ||
| Total cholesterol (mg/dL)a | 219 ± 52 | ||
| LDL-cholesterol (mg/dL)a | 133 ± 50 | ||
| HDL-cholesterol (mg/dL)a,b | 42 ± 13 | ||
| VLDL-cholesterol (mg/dL)a | 33 [27–45] | ||
| Triglycerides (mg/dL)a | 165 [135–226] | ||
| HbA1c (%) (mmol/L)a | 7.7 ± 1.2 (61 ± 0.1) | ||
| Glucose (mg/dL)a | 164 ± 43 | 137 [125–191] | 130 [109–163]* |
| Insulin (μIU/mL)a | 20 ± 14 | 19 ± 14 | 15 ± 8 |
| C-peptide (ng/mL)a | 3.8 ± 1.8 | 3.8 ± 1.8 | 3.6 ± 1.6 |
| GLP-1 (pg/mL)a | 719 ± 179 | 688 ± 209 | 689 ± 205 |
| Glucagon (pg/mL)a | 73 [57–88] | 70 ± 17 | 74 ± 24 |
| NEFA (mmol/L)a | 0.61 ± 0.19 | 0.61 ± 0.19 | 0.58 ± 0.16 |
| HOMA-IR | 4.8 [2.2-10.1] | 4.7 [2.6-7.6] | |
| QUICKI | 0.30 ± 0.03 | 0.31 ± 0.03 | |
| Adipo-IR | 9.9 [5.7-14.9] | 8.8 [6.0-10.6] | |
| Matsuda indexc | 3 ± 2 | 3 ± 1.2 | |
| Insulinogenic indexc | 0.3 [0.1-0.65] | 0.56 [0.28-0.73]* | |
Values are presented as mean ± SD or median [interquartile range] or number (n) followed by the respective proportion (%). n = 16.
means p < 0.05 using paired Student t-test or Wilcoxon matched-pairs for symmetric and asymmetric data, respectively.
BMI: body mass index; T2DM: type 2 diabetes mellitus; SAP: systolic arterial pressure; DAP: diastolic arterial pressure; LDL: low-density lipoprotein; HDL, high-density lipoprotein; VLDL: very-low-density lipoprotein; HbA1c: haemoglobin A1c; GLP-1: glucagon-like peptide-1; NEFA: non-esterified fatty acids; HOMA: homeostasis model assessment of insulin resistance; QUICKI: quantitative insulin sensitivity check index; Adipo-IR: adipose tissue insulin resistance.
Under fasting.
No differences between man and women values.
Insulinogenic index and Matsuda index were obtained from the CHO meal test.