Table 4. Summary of literature: validation of fiber orientations.
Studies that have compared dMRI orientation estimates in post-mortem brain tissue to independent measurements of fiber orientations from a reference modality in the same sample. We list the reference modality, type of tissue, and dMRI acquisition parameters for each study (“iso” indicates isotropic voxels).
| Reference modality |
Tissue type |
dMRI b-values [s/mm2] |
Gradient directions | Voxel size [mm] | ||
|---|---|---|---|---|---|---|
| Leergaard et al. (2010) | Myelin stain | 2D | Rat | Max 30452 | 514 | .265 iso |
| Choe et al. (2012) | 2D | Owl monkey | 1309 | 21 | .3 iso | |
| Seehaus et al. (2015) | 2D | Human | 3000 | 60 | .34 iso | |
| Schilling et al. (2017a) | 2D | Macaque | 6000 | 101 | .3-.8 iso | |
| Schilling et al. (2016) | DiI | 3D | Squirrel monkey | 3200/6400 | 30/90 | .4 iso |
| Schilling et al. (2018) | 3D | Squirrel monkey | 3000/6000 9000/12000 | 100/100 100/100 | .2 x .2 x .4 | |
| Mollink et al. (2017) | PLI | 2D | Human | 5000 | 120 | .4 iso |
| Henssen et al. (2019) | 2D | Human | 4000 | 256 | .5 iso | |
| Wang et al. (2014b) | PSOCT | 2D | Human | 4032 | 20 | .3 iso |
| Jones et al. (2020) | 2D | Human | Max 40000 | 514 | .25 iso | |
| Jones et al. (2021) | ||||||
| Stolp et al. (2018) | CLARITY | 3D | Mouse | 1500 | 42 | .125 x .125 x .2 |
| Leuze et al. (2021) | 3D | Human | 2000 | 447 | 1.0 iso |