Fig. 3.

SCD-153 shows time- and dose-dependent cytotoxicity on NHEKs. Viability (%) of NHEKs incubated with SCD-153, DMI, and 4-MI at various concentrations and durations. NHEKs showed decreased viability after 8 hours of incubation with SCD-153, at drug concentrations above 100 μM (n = 2 per compound at each concentration). Separate but chemically identical samples of SCD-153 were prepared at the Institute of Organic Chemistry and Biochemistry (IOCB) and the Sun Pharma Advanced Research Company (SPARC). Data are expressed as mean ± SEM.