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. 2022 Dec 16;2(1):pgac297. doi: 10.1093/pnasnexus/pgac297

Fig. 4.

Fig. 4.

SCD-153 inhibits poly I:C- and IFNγ- induced expression of proinflammatory cytokines in NHEKs. (a) SCD-153 caused dose-dependent inhibition of poly I:C-induced IL-6 and TLR3 expression in NHEKs at 8 hours of incubation ( n = 2 per condition for incubation time of 8 hours, n  = 1 per condition for other incubation times). (b) SCD-153 caused dose-dependent inhibition of poly I:C-induced IL-6, IL-1β, and IFNβ expression and IFNγ-induced IL-6 expression in NHEKs ( n = 2 per condition). P values were calculated by one-way ANOVA followed by Dunnett's multiple comparisons test. * P < 0.05, ** P < 0.01, *** P  < 0.001 compared to poly I:C or IFNγ alone. Data are expressed as mean ± SEM.