Skip to main content
. 2022 Dec 16;2(1):pgac297. doi: 10.1093/pnasnexus/pgac297

Fig. 5.

Fig. 5.

Topical application of 3% SCD-153 induces early telogen to anagen transition in C57BL/6 mice. (a) Female C57BL/6 mice underwent hair clipping at 8.5 weeks after birth (during the telogen phase of the hair growth cycle), followed by four doses of topical treatment on the dorsal right side with vehicle (DMSO), 3% 4-MI, or 3% SCD-153 on days 1, 3, 5, and 7 after hair clipping. (b) Number and (c) Photographs of mice showing skin erythema and scaling on day 9, as well as hair growth on day 18. (d) Difference in mean pixel intensity between the treated and untreated sides of mice measured from photographs that were converted to 8-bit grayscale images, with negative change in mean pixel intensity suggestive of hair growth and skin darkening. SCD-153 in this experiment was prepared at SPARC. Dots on the bar graph represent measurements of individual mice (n = 6 per group). P values were calculated by one-way ANOVA followed by Tukey's multiple comparisons test. * P < 0.05. Data are expressed as mean ± SEM.