Table 1:

Studies on the toxic effect of pyridostigmine bromide.

Pyridostigmine Bromide
Study (Ref #)	Model	Exposure	Results
Bryant et al., 2021 (23)	Male and female C57BL/6 mice (WT, NLRP3−/−, and STINGgt/gt)	0.7 mg/kg PB and 200 mg/kg Per in 50 mL DMSO daily for 10 days	Greater neuroinflammation and cognitive impairment in female mice; greater peripheral inflammation in males
Hernandez et al., 2020 (25)	Male and female C57BL/6 mice	90 mg/mL PB in drinking water for 7 days; 0.07 mg/mL PEA in drinking water for one month	PB alone increased fecal pellet production and colonic transit time only in females, PB+PEA increased myenteric neurons and muscarinic M3 receptors only in females
Hernandez et al., 2019 (26)	Male and female C57BL/6 mice	9 or 90 mg/mL PB in drinking water for 7 days	PB-induced neuroimmune effects seen in males immediately after treatment, but not in females until 30 days after beginning of treatment