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. 2022 Nov 30;108(1):115–123. doi: 10.4269/ajtmh.22-0256

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Figure 2. — Antispike binding antibody (Bab) titers before messenger RNA (mRNA)-1273 booster and time since most recent “spike antigen exposure.” Scatterplot of antispike Bab titers before mRNA-1273 booster and time since most recent spike antigen exposure (either by the CoronaVac second dose or SARS-CoV-2 infection, whichever was the most recent). Pre-mRNA-1273 boost Bab titers were higher overall in previously infected-vaccinated than in naive-vaccinated participants. Pre-mRNA-1273 boost Bab titers correlated inversely with the time since the most recent documented spike antigen exposure. Participants with a breakthrough infection post-CoronaVac (vaccinated-infected) had the shortest time since most recent spike antigen exposure, and had a higher pre-mRNA-1273 boost Bab titer than those infected before CoronaVac (infected-vaccinated) and naive-vaccinated participants. BAU = binding antibody units.