Table 1.

Clinical, economic, and resource inputs to model, all 2021 US dollars

	Default
Clinical inputs to the model
Parameter
Probability of extended ED stay, standard of care	0.0409
Probability of extended ED stay, fluvoxamine	0.0081
Probability of hospital admission, standard of care	0.1228
Probability of hospital admission, fluvoxamine	0.1001
Probability of admission to ICU, given if hospitalized	0.2224
Economic cost inputs to the model
Drug costs
Fluvoxamine 10-day course	$7.42
Nirmatrelvir–ritonavir therapy, 5 days	$529.00
Standard of care	$0.00
Hospital services costs
ED visit	$608.46
Extended ED visit (incremental)	$200.79
Hospital admission	$6,956.08
ICU admission	$14,887.30
Length of stay for respiratory admission
ED visit	0.0
Extended ED visit	0.0
Pneumonia with or without complications or comorbidities	3.1
RSD with < 96 hours of ventilator support	5.8
RSD with > 96 hours of ventilator support	22.6
RSD ICU admission	16.0

ED = emergency department; ICU = intensive care unit; RSD = respiratory system diagnosis.