Table 3.
Univariate and multivariate analysis of Leiden x CAD for major cardiovascular events.
| Univariate HR (95%CI) | p-Value | Leiden x CAD |
||
|---|---|---|---|---|
| Multivariate HR (95%CI) | p-Value | |||
| Age, yrs | 1.03 (1.01–1.05) | <0.001 | 1.02 (1.00–1.04) | 0.017 |
| Male | 1.31 (0.92–1.85) | 0.136 | 1.18 (0.82–1.71) | 0.364 |
| BMI (kg/m2) | 1.00 (0.95–1.05) | 0.994 | ||
| Cardiac risk factors | ||||
| Hypertension | 1.19 (0.82–1.73) | 0.372 | ||
| Hyperlipidemia | 1.69 (1.18–2.43) | 0.004 | 1.82 (1.26–2.63) | 0.001 |
| Current smoker | 1.42 (0.99–2.04) | 0.057 | ||
| Family history of CAD | 0.84 (0.55–1.27) | 0.401 | ||
| CCTA findings | ||||
| High-risk plaque | 4.71 (3.00–7.40) | <0.001 | 3.08 (1.93–4.91) | <0.001 |
| CAD severity (Leiden x CAD) | ||||
| Normal | 1 | 1 | ||
| Non-obstructive Leiden<5 | 1.86 (0.70–4.99) | 0.216 | 1.69 (0.63–4.52) | 0.299 |
| Non-obstructive Leiden≥5 | 4.04 (1.55–10.52) | 0.004 | 3.24 (1.24–8.47) | 0.017 |
| Obstructive | 7.63 (3.09–18.83) | <0.001 | 5.46 (2.18–13.68) | <0.001 |
CAD, coronary artery disease; CCTA, coronary computed tomography angiography.