Fig. 1.

Predictors of Male: Main risk factors promoting the atherosclerotic process underlying peripheral artery disease. All possible predictors of major adverse limb events. MALE: Major Adverse Limb Event; BMP’s: Bone Morphogenetic Proteins; VSMCs: Vascular Smooth Muscle Cell; NFkB: Nuclear Factor Kappa-light-chain-enhancer of activated B cells; ROS: Reactive Oxygen Species; LDL: Low-Density Lipoprotein; eNOs: endothelial Nitric Oxide Synthase; MACE: Major Adverse Cardio/Cerebrovascular Event; ABI: Ankle-Brachial Index.