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TACE/ADAM17 substrates in ACS and follow-up MACE. Levels of TACE/ADAM17 substrates TRANCE, LDLR, LAG-3 and ACE2 were significantly higher in CAD patients compared to controls. Levels of HB-EGF, Ep-CAM, TNFR1 were able to accurately classify ACS patients and levels of TNFR1 and TNFR2 associated with MACE upon follow-up. TACE inhibitor, TIMP3 mRNA levels were lower in CAD patients and tended to be lower in ACS compared to elective CAD patients.
