Table 4.
Logistic regression analysis. Multivariable regression analysis of NPX values demonstrates that TNFR1, HB-EGF and Ep-CAM plasma levels were each independently associated with ACS after adjustment for creatinine, smoking status, previous MI, stent or bypass and previous CAD medications for each variable separately.
| ELEC (n = 104) |
ACS (n = 95) |
Exp(B) | p valuea | 95% CI for EXP(B) |
||||
|---|---|---|---|---|---|---|---|---|
| mean (NPX) | Sd | mean (NPX) | Sd | Lower | Upper | |||
| TNFR1 | 5.63 | 0.52 | 5.98 | 0.71 | 3.24 | 0.002 | 1.51 | 6.92 |
| HB-EGF | 5.16 | 0.76 | 4.77 | 0.63 | 0.48 | 0.006 | 0.29 | 0.81 |
| Ep-CAM | 4.95 | 0.96 | 4.54 | 0.86 | 0.56 | 0.004 | 0.37 | 0.83 |
ACS: Acute coronary syndrome; ELEC: Elective CAD patients, NPX: Normalised protein expression.
TIMP3 is downregulated in CAD and tends to be lower in patients admitted with ACS compared to those admitted electively.
a
Each of TNFR1, HB-EGF and EpCAM were individually adjusted for creatinine levels, smoking, previous MI, stent or bypass and previous CAD medsRef category is ELEC.