Table 2.
Laboratory characteristics of patients with FH, according to the degree of coronary calcification and the extension of coronary atherosclerosis.
| Variable | Total (N = 92) | CAC = 0 (N = 40) | CAC>0 (N = 52) | p-value | CAD-RADS < median (N = 38) | CAD-RADS ≥ median (N = 53) | p-value |
|---|---|---|---|---|---|---|---|
| Total cholesterol, mg/dL | 233 (186–296) | 241 (193–300) | 233 (182–292) | 0.720 | 242 (64) | 240 (68) | 0.935 |
| HDL-c, mg/dL | 54 (43–65) | 52 (43–65) | 55 (43–66) | 0.595 | 53 (43–65) | 55 (43–66) | 0.878 |
| LDL-c, mg/dL | 141 (104–202) | 133 (105–205) | 145 (104–202) | 0.978 | 133 (104–200) | 144 (107–202) | 0.699 |
| Non-HDL-c, mg/dL | 173 (131–237) | 177 (133–249) | 177 (127–237) | 0.711 | 185 (65) | 185 (66) | 0.968 |
| Triglycerides, mg/dL | 135 (96–176) | 175 (127–237) | 143 (95–179) | 0.587 | 145 (68) | 142 (63) | 0.819 |
| Apo A1, mg/dL | 149 (129–151) | 141 (126–171) | 149 (129–170) | 0.511 | 145 (131–173) | 145 (127–170) | 0.949 |
| Apo B, mg/dL | 114 (88–142) | 119 (91–138) | 107 (84–144) | 0.741 | 119 (93–140) | 107 (84–143) | 0.629 |
| Lp(a), mg/dL | 23 (8–53) | 23 (8–56) | 23 (8–51) | 0.606 | 22 (9–61) | 24 (7–53) | 0.678 |
| Fasting glucose, mg/dL | 93 (85–106) | 93 (85–106) | 95 (87–108) | 0.322 | 93 (85–103) | 94 (87–107) | 0.387 |
| HbA1c, % | 5.8 (5.5–6.1) | 5.7 (5.4–6.1) | 5.8 (5.6–6.0) | 0.760 | 5.8 (5.5–6.1) | 5.8 (5.6–6.0) | 0.984 |
| AST (U/L) | 20 (16–26) | 21 (17–27) | 19 (15–24) | 0.119 | 21 (17–27) | 19 (15–24) | 0.253 |
| ALT (U/L) | 21 (15–26) | 22 (15–31) | 21 (15–25) | 0.452 | 22 (15–31) | 21 (15–25) | 0.518 |
| CK (U/L) | 135 (110–241) | 154 (108–181) | 135 (110–252) | 0.619 | 149 (107–179) | 135 (110–252) | 0.486 |
| TSH (μIU/L) | 2.14 (1.63–3.43) | 1.93 (1.63–2.82) | 2.56 (1.65–4.18) | 0.030 | 1.93 (1.63–2.66) | 2.56 (1.66–4.02) | 0.038 |
| Creatinine (mg/dL) | 0.91 (0.73–1.10) | 0.87 (0.73–1.08) | 1.00 (0.73–1.20) | 0.339 | 0.85 (0.72–1.07) | 1.00 (0.73–1.14) | 0.229 |
| hs-CRP (mg/L) | 1.60 (0.78–3.60) | 1.23 (0.66–3.13) | 1.67 (0.78–4.15) | 0.434 | 1.23 (0.69–3.30) | 1.67 (0.81–4.07) | 0.463 |
| Serum IgM (dilution) | 51,200 (51,200–102,400) | 102,400 (51,200–102,400) | 51,200 (51,200–102,400) | 0.156 | 102,400 (51,200–102,400) | 51,200 (51,200–102,400) | 0.106 |
| Serum IgM (LN10) | 4.71 (4.71–5.01) | 5.01 (4.71–5.01) | 4.71 (4.71–5.01) | 0.156 | 5.01 (4.71–5.01) | 4.71 (4.71–5.01) | 0.106 |
| LDL-c-year-score, mg | 14,342 (10,131–20,604) | 11,954 (7,760–16,810) | 14,762 (11,520–21,830) | 0.011 | 12,938 (7,920–17,030) | 14,758 (10,721–21,750) | 0.038 |
Numerical variables expressed as median (IQR) and compared by Mann-Whitney test.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAC, coronary artery calcification score; CAD-RADS, Coronary Artery Disease – Reporting and Data System; CK, creatine phosphokinase; HDL, high-density lipoprotein; hs-CRP, high-sensitivity C-reactive protein; IgM, immunoglobulin M; IQR, interquartile range; LDL, low-density lipoprotein; Lp(a), lipoprotein (a); TSH, thyroid-stimulating hormone.