Table 4.
Crude and adjusted linear regression models with CAC or CAD-RADS as dependent variable in participants with familial hypercholesterolemia.
| Models for CAC | Unstandardized coefficients |
Standardized coefficients |
t |
Sig. |
95% CI for B |
Statistics of collinearity |
|||
|---|---|---|---|---|---|---|---|---|---|
| B | Standard model | Beta | Lower-bound | Upper-bound | Tolerance | VIF | |||
| 1 (Constant) | −110.027 | 156.726 | −0.702 | 0.485 | −412.537 | 201.483 | |||
| Age | 5.078 | 2.780 | 0.192 | 1.827 | 0.071 | −0.448 | 10.603 | 1.000 | 1.000 |
| 2 (Constant) | −130.247 | 268.476 | −0.515 | 0.608 | −671.659 | 395.465 | |||
| Age | 4.952 | 2.958 | 0.187 | 1.674 | 0.098 | −0.929 | 10.833 | 0.893 | 1.120 |
| SBP | 0.288 | 2.219 | 0.015 | 0.130 | 0.897 | −4.124 | 4.700 | 0.893 | 1.120 |
| 3 (Constant) | 58.752 | 319.781 | 0.183 | 0.855 | −577.237 | 694.382 | |||
| Age | 3.862 | 3.107 | 0.146 | 1.243 | 0.217 | −2.316 | 10.041 | 0.807 | 1.239 |
| SBP | −0.136 | 2.247 | −0.007 | −0.060 | 0.952 | −4.604 | 4.333 | 0.868 | 1.152 |
| IgM-anti ApoB-D | −72.718 | 64.428 | −0.130 | −1.129 | 0.262 | −200.819 | 55.383 | 0.839 | 1.192 |
| 4 (Constant) | −128.488 | 322.279 | −0.566 | 0.573 | −823.375 | 458.399 | |||
| Age | 5.088 | 3.039 | 0.193 | 1.674 | 0.098 | −0.956 | 11.131 | 0.788 | 1.269 |
| SBP | −0.660 | 2.181 | −0.033 | −0,303 | 0.763 | −4.997 | 3.678 | 0.861 | 1.161 |
| IgM-anti ApoB-D | −93.692 | 62.779 | −0.168 | −1.492 | 0.139 | −218.535 | 31.151 | 0.825 | 1.212 |
| CD4+T lymphocytes |
35.289 |
13.357 |
0.277 |
2.642 |
0.010 |
8.727 |
61.851 |
0.945 |
1.058 |
| Models for CAD-RADS score | Unstandardized coefficients | Standardized coefficients | t | Sig. | 95% CI for B | Statistics of collinearity | |||
| B | Standard model | Beta | Lower-bound | Upper-bound | Tolerance | VIF | |||
| 1 (Constant) | −0.462 | 0.669 | −0.690 | 0.492 | −1.792 | 0.868 | |||
| Age | 0.033 | 0.012 | 0.290 | 2.815 | 0.006 | 0.010 | 0.057 | 1.000 | 1.000 |
| 2 (Constant) | −0.903 | 1.118 | −0.807 | 0.422 | −3.125 | 1.320 | |||
| Age | 0.031 | 0.013 | 0.271 | 2.454 | 0.016 | 0.006 | 0.056 | 0.878 | 1.138 |
| SBP | 0.005 | 0.009 | 0.055 | 0.493 | 0.623 | −0.014 | 0.023 | 0.878 | 1.138 |
| 3 (Constant) | −0.022 | 1.359 | −0.016 | 0.987 | −2.724 | 2.680 | |||
| Age | 0.026 | 0.013 | 0.227 | 1.940 | 0.056 | −0.001 | 0.052 | 0.781 | 1.280 |
| SBP | 0.003 | 0.009 | 0.033 | 0.290 | 0.772 | −0.016 | 0.021 | 0.852 | 1.173 |
| IgM-anti ApoB-D | −0.317 | −0.279 | −0.130 | −1.137 | 0.259 | −0.872 | 0.238 | 0.816 | 1.226 |
| 4 (Constant) | 0.290 | 1.375 | 0.211 | 0.834 | −2.444 | 3.024 | |||
| Age | 0.027 | 0.013 | 0.234 | 2.001 | 0.049 | 0.000 | 0.053 | 0.780 | 1.283 |
| SBP | 0.001 | 0.009 | 0.017 | 0.153 | 0.879 | −0.017 | 0.020 | 0.843 | 1.187 |
| IgM-anti ApoB-D | −0.291 | 0.279 | −0.120 | −1.045 | 0.299 | −0.846 | 0.263 | 0.811 | 1.232 |
| Endothelial MP | −1.766 | 1.367 | −0.135 | −1.292 | 0.200 | −4.484 | 0.952 | 0.980 | 1.012 |
Apo, apolipoprotein; CAC, coronary artery calcification score; CAD-RADS, Coronary Artery Disease – Reporting and Data System; CD, cluster differentiation; Ig, immunoglobulin; SBP, systolic blood pressure; VIF, variance inflation factor.