TABLE 1.

Serum cytokine and NO levels in uninfected and P. chabaudi AS-infected WT and GKO mice^a

Cytokine or NO and mouse type	Levelb in mice that were:
	Uninfected		Infected
	Male	Female	Male	Female
IL-12p70
WT	0.27 ± 0.04	0.27 ± 0.06	2.97 ± 0.3*	3.32 ± 0.19*
GKO	0.22 ± 0.03	0.16 ± 0.08	0.71 ± 0.20	0.78 ± 0.14
IFN-γ
WT	1.3 ± 0.2	1.1 ± 0.2	32.3 ± 3.6	50.8 ± 4.3#
GKO	NDc	ND	ND	ND
TNF-α
WT	0.32 ± 0.05*	0.31 ± 0.02*	1.25 ± 0.10*	1.01 ± 0.10*
GKO	0.15 ± 0.02	0.22 ± 0.01	0.39 ± 0.03	0.40 ± 0.02
NO
WT	9.8 ± 2.0	5.1 ± 1.3	59.6 ± 6.5*	76.2 ± 5.8*
GKO	9.9 ± 3.0	4.8 ± 0.9	11.1 ± 1.2	9.2 ± 1.6

^aLevels of IL-12 p70 in serum of infected mice were analyzed on day 2, and levels of IFN-γ, TNF-α, and NO were analyzed on day 7, following P. chabaudi AS infection. Data are means ± SEM for three to five mice per group. Results from one of three replicate experiments are shown. 

^bUnits are nanograms per milliliter for cytokines and micromolar for NO. ∗, P < 0.01 for WT versus GKO mice; #, P < 0.01 for WT female versus male mice. 

^cND, not detectable.