Table 3. Cox regression analysis of the predictors related to overall survival in the study cohort (N = 724 lung cancer patients).

*Age as a continuous variable.

Reference variables: Male gender; no comorbidity; adenocarcinoma histology; stage I/II; non-smokers; not received targeted/ immunotherapy.

HR = Hazard ratio, CI = Confidence interval

	Univariate Cox regression			Multivariate Cox regression
Predictor variable	HR	95% CI	P-value	HR	95% CI	P-value
Female	0.84	0.69-1.04	0.11
Presence of comorbidity	0.97	0.79-1.20	0.81
*Age	1.02	1.007-1.02	<0.001	1.02	1.01-1.02	<0.001
Non-adenocarcinoma histology	1.23	1.03-1.47	0.023	1.22	1.01-1.49	0.04
Stage III	2.17	1.12-4.26	0.024	2.39	1.22-4.71	0.01
Stage IV	4.32	2.30-8.12	<0.001	5.35	2.83-10.10	<0.001
Smokers	1.26	1.05-1.51	0.01	1.18	0.97-1.45	0.09
Received targeted therapy/ immunotherapy	0.8	0.64-0.99	0.04	0.75	0.59-0.95	0.02