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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Nat Genet. 2022 Sep 26;54(10):1564–1571. doi: 10.1038/s41588-022-01180-2

Extended Data Fig. 1. Allele balance is not generally correlated between PTA amplifications.

Extended Data Fig. 1

a. Genome-wide allele balance (binned in 100 kb windows) for 3 typical PTA cells from the same individual. b. Allele balance for cells in (a) plotted against each other. c-d. Allele balance averaged across the cohort of 52 PTA cells (c) or 75 MDA cells (d); i.e., each point represents the average allele balance for a single 100 kb window. A small number of regions show consistent allelic imbalance across many amplifications (arrows). e. Correlation of allele balance profiles between all pairs of PTA cells. Correlation is generally low; cells from the same individual show slightly higher correlations; and a single individual (4638) shows the strongest correlation.