TABLE 2.

Protection of gerbils from amebic liver abscess by intraperitoneal or oral vaccination with CtxB–170CR2-PEP5 chimeras

Vaccine route and group	No. of gerbils with liver abscess/no. of gerbils challenged	% Liver abscessed (mean ± SD)
Intraperitoneal
CtxB	9/9	12.1 ± 11.2
CtxB+T	6/6	7.4 ± 3.6
CtxB+N	7/11	4.7 ± 5.5
CtxB+M	5/5	7.0 ± 2.0
CtxB+C	5/11	1.4 ± 1.9a
Oral
Trial 1b
CtxB	6/6	16.0 ± 6.9
CtxB+N	6/6	4.4 ± 2.1
CtxB+C	6/6	6.8 ± 2.6
Trial 2c
CtxB	10/10	9.5 ± 4.5
CtxB+N	8/10	3.3 ± 3.3d
CtxB+C	7/10	2.4 ± 2.3e

^aP < 0.006. 

^bImmunization on day 0, 14, and 28. 

^cImmunization on day 0, 14, 28, and 90. 

^dP < 0.006. 

^eP < 0.002.