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. Author manuscript; available in PMC: 2023 Jan 11.
Published in final edited form as: Nat Aging. 2022 Oct 12;2(10):923–940. doi: 10.1038/s43587-022-00290-0

Extended Data Fig. 7. Proteomic comparison of the three mouse models and AD.

Extended Data Fig. 7.

a, The workflow to examine the consistent changes in the three mouse models and human AD cases by overlapping differentially expressed proteins. b, DE protein numbers in the mouse models, human cases, and the overlapped portions. c, Enriched pathways of the human-overlapped DE proteins in three genotypes (selected from supplementary table 19, Fisher's exact test and the BH procedure to derive FDR, FDR cutoff of 0.05). d, Enriched protein-protein interaction modules (selected from supplementary table 20, Fisher's exact test and the BH procedure to derive FDR). FDR cutoff is 0.05 except the Aβ binding module, which is selected due to biological significance.