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. Author manuscript; available in PMC: 2023 Jan 11.
Published in final edited form as: Cell Rep. 2022 Dec 13;41(11):111797. doi: 10.1016/j.celrep.2022.111797

Figure 3. Enhanced CCR2-mediated monocyte recruitment drives pathogenic tissue remodeling in CF lungs.

Figure 3.

(A and B) Representative subgross H&E images of lung from WT, CF, dKO, and CCR2−/− mice at T0, T1, and T2. Black stars indicate enlarged alveolar spaces. Scale bars: 500 μm (A) and 50 μm (B).

(C) Relative alveolar disruption score from semiquantification analysis of lung histology. Bars are depicted as means ± SEM for 4 or more mice per genotype and time point.

(D) Relative weight loss of mice after week 1 of LPS administration. Each dot represents one biological replicate.

r multiple comparisons between the genotypes for each time point separately (*p < 0.05, **p < 0.01, ***p < 0.001). See also Figures S4, S5, and S6.