FIG. 4.

Comparisons of TNF-α secretion from C3Heb/FeJ (endotoxin-normoresponsive) versus C3H/HeJ (endotoxin-hyporesponsive) mouse macrophages cocultured with viable bacteria for 0 to 6 h. Macrophage and bacterial preparations and the TNF-α assay were as described for Fig. 1, except that each bacterial concentration was 10-fold lower: E. coli O111:B4 concentration, 5 × 10⁴ CFU/ml; S. aureus M concentration, 5 × 10⁴ CFU/ml. Data are means ± SEM for three independent experiments. For the data lacking error bars, variation was too small to indicate.